p53Lab


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The p53 lab is focusing on the development of new therapies, new diagnostics and new discoveries in the p53 pathway. 11 Million people living with cancer have specific mutations in the p53 gene leading to the production of a faulty p53 protein. This is half the cases of human cancer. In those that have an apparently normal p53 gene we believe that there are faults in the p53 pathway. We are using a variety of approaches to translate this extraordinary finding into clinical benefit. We work closely with many other groups both in Singapore and in the rest of the world to acheive this. We are using biochemical, biophysical, cell biological and genetic approaches in our work and offer an outstanding international training environment.

Current Publications

Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Goh AM, Lim CY, Chiam PC, Li L, Mann MB, Mann KM, Menendez S, Lane DP. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1685-90.

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Lane DP, Madhumalar A, Lee AP, Tay BH, Verma C, Brenner S, Venkatesh B. Cell Cycle. 2011 Dec 15;10(24):4272-9.

New insights into p53 based therapy. Lane DP, Brown CJ, Verma C, Cheok CF. Discov Med. 2011 Aug;12(63):107-17.

Mechanism-specific signatures for small-molecule p53 activators. van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, Westwood NJ, Laín S. Cell Cycle. 2011 May 15;10(10):1590-8. Epub 2011 May 15.

Current Highlights

Leica M165FC Stereomicroscope. Click here for more information

Biacore T100. Click here for more information

Nanodrop ND8000. Click here for more information

Envision Multilabel Plate Reader. Click here for more information

CFX 96 Real-Time PCR Detection System. Click here for more information

Research Area

		P53 Pathway

		Protein Peptide Interactions

		Mechanism Of Drug Action